As shown previously by our group, ablation of PHD2 in different murine tumor cell lines such as Lewis lung carcinoma (LLC) model, B16 melanoma, and LM8 osteosarcoma, led to a significant increase in tumor vasculature, followed by a significant reduction in tumor growth due to enhanced MMP activity and TGF-β release within the tumor microenvironment (TME) [27,32]. The gene discussed is EGLN1; the disease is neoplasm.