Suppressing alpha-smooth muscle actin (α-SMA) myofibroblastic CAFs—which share the phenotypic traits of fibroblasts and smooth muscle cells, secrete ECM, and generate mechanical tension within tissue through cell contraction [46]—through the inhibition of plasminogen activator inhibitor-1 (PAI-1) limits resistance to cisplatin in lung cancer [47]. The gene discussed is SERPINE1; the disease is lung cancer.