IGF1 and cancer: The secretome of CAFs consists of several growth factors and cytokines [8], including connective tissue growth factor (CTGF), epidermal growth factor (EGF), insulin-like growth factor (IGF), hepatocyte growth factor (HGF), basic FGF (bFGF), nerve growth factor (NGF), and IL-6, which promote cancer cell survival as well as its proliferative and invasive behavior.