The same research team further demonstrated that the combination of cyst(e)inase, an engineered enzyme which degrades both cystine and cysteine, and ICB therapy synergistically impairs cystine uptake via xCT in tumor cells, resulting in GSH deficiency, ROS accumulation, lipid peroxidation, and ferroptosis of cancer cells in preclinical models [164]. Here, SLC7A11 is linked to cancer.