Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor that has been proposed as a therapeutic target for metabolic syndromes, including obesity, due to its mediation in triggering metabolic regulators such as PPARγ and antioxidant response element (ARE) in the liver and WAT [139]. This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.