Another two positive feedback loops have been found to coexist in multidrug-resistant hepatocellular cancer cells, HIF-1α/miR-183/IDH2/HIF-1α and HIF-1α/miR-183/SOCS6/p-STAT3/HIF-1α, which may modulate HIF-1α protein [127]. Here, HIF1A is linked to hepatocellular carcinoma.