HIF1A and nasopharyngeal carcinoma: Further studies conducted on nasopharyngeal carcinoma, proposed a new putative mechanism by which PVT1 could stabilize HIF-1α [109]; here, the authors demonstrated that the lncRNA functions as a scaffold for the chromatin modification factor KAT2A, which stabilizes HIF-1α via H3K9ac/TIF1β complex-mediated NF90 (a double-stranded RNA-binding protein) transcriptional activation [109].