SPNS2 and metastatic malignant neoplasm in the lymph nodes: Table 2 lists the correlation between SPNS2 protein expression and clinicopathological variables in the OSCC patients, with the research cohort divided into subgroups depending on whether they tested negative or positive for cytoplasmic SPNS2 expression. Cytoplasmic SPNS2 expression was correlated with T status (p = 0.026) and stage (p = 0.011); however, no correlation was observed between SPNS2 expression and age, gender, histological grade, lymph node metastasis, distant metastasis, smoking, chewing betel nut, or survival (p > 0.05) (Table 2).