CFLAR and neoplasm: Remarkably, published studies from our laboratory demonstrated that 2-Methoxyestradiol (2-ME2) (i) inhibited growth of PCa cells by downregulating Sp1-mediated transactivation of c-FLIP [16,17] and (ii) caused tumor regression with associated reduction in c-FLIP protein levels in transgenic adenocarcinoma of the mouse prostate (TRAMP) model [16,17].