The AQP3-KO rat model of colitis induced by dextran sulphate or acetic acid developed more severe colonic hemorrhage, marked epithelial cell loss and death than observed in wild-type rats, and these symptoms were significantly reversed by oral glycerol uptake, increasing survival and reducing the severity of colitis, and suggesting that AQP3 is implicated in enterocyte proliferation due to its glycerol facilitator function [67]. The gene discussed is AQP3; the disease is colitis.