IGF2 and Alzheimer disease: In another genetic model of AD, APPswe.PS1dE9 mice, i.c.v. administration of IGF-2 not only reduced the number of hippocampal Aβ-positive plaques but also partially restored the damages in cholinergic system: IGF-2 treatment increased the levels of both choline acetyltransferase (CHAT) and cholinergic differentiating factor, BMP9 [256].