TGFB1 and neoplasm: Several different tumor-related soluble molecules are involved in this form of immunosuppression: Vascular Endothelial Growth Factor (VEGF), Prostaglandin E2, TGF-β, IL-10, soluble phosphatidylserine, MICA Fas and FasL100 [27,28,29,30,31,32,33,34].