Indeed, the immunohistochemistry and gene-expression analysis of surgically removed partially irradiated squamous cell and adenocarcinoma NSCLCs following SBRT-PATHY, and non-irradiated but regressing abscopal tumor sites, showed activation of immune system in the radiation-spared TME with very dense infiltration of T-lymphocytes, with more or less pronounced predominance of CD8+ cytotoxic lymphocytes [118]. The gene discussed is CD8A; the disease is neoplasm.