Among these are cancer/germline antigens (e.g., MAGE-A1, MAGE-A3, and NY-ESO-1); cell lineage differentiation antigens (e.g., tyrosinase, gp100, MART-1, prostate-specific antigen (PSA), and prostatic acid phosphatase (PAP)); and antigens that are overexpressed in cancer cells (e.g., hTERT, HER2, mesothelin, and MUC-1). Here, TYR is linked to cancer.