This also presents multiple advantages over direct i.t. injection, considering the difficulty of the direct administration into tumors within deep tissues [5,6,7], with such sites potentially providing insufficient volumes for injection [5,7], and the frequent absence of tertiary lymphoid structures/niches within the tumor, which are thought to play a pivotal role in facilitating CD8+ T cell infiltration, survival, and instruction [8,9,10]. Here, CD8A is linked to neoplasm.