KLK3 and bone metastasis: Table 3 also presents the results of univariate and multivariate Cox proportional hazard analyses for PFS. The univariate analysis showed that bone metastasis (p = 0.0047), PSA (p < 0.0001), alkaline phosphatase (p = 0.0042), testosterone (p = 0.0049), and Hs-mGPS (p = 0.0078) were significant prognostic factors associated with PFS. The multivariate analysis showed that Hs-mGPS (p = 0.0945) was not significantly prognostic for PFS.