Since the APCDD1 gene has been linked to CRC by being involved in the Wnt signaling pathway as a direct target of the beta-Catenin/TCF4 complex, the associated variant (p.R299H) was prioritized as the top cancer-predisposing candidate of all identified missense variants (Figure 2) [25]. The gene discussed is APCDD1; the disease is colorectal carcinoma.