Sequencing studies have further identified germline variants in HNRNPA0 and WIF1 genes in a family with susceptibility to multiple early onset cancers including CRC [4] as well as a germline mutation in NTHL1 gene in three unrelated families with adenomatous polyposis and various cancer types including CRC [5,6]. Here, HNRNPA0 is linked to colorectal carcinoma.