Checking the shortlisted variants for their involvement in molecular mechanisms of colorectal carcinogenesis such as Wnt and Notch signaling pathways, which are generally known to play a crucial role in CRC initiation [29], revealed that the HDAC5 gene was implicated in colorectal carcinogenesis by upregulating the Delta-like 4 ligand (DLL4), a vascular specific Notch ligand essential for tumor angiogenesis [30,31]. This evidence concerns the gene DLL4 and colorectal carcinoma.