Though a cell growth-promoting function was reported by Takahashi et al. for APCDD1 in vitro and in vivo using colon cancer LoVo cells [25], cell proliferation assays of this study using HEK293T and colon cancer cells HT-29 could not confirm the postulated proliferative impact of wild-type APCDD1 nor of the identified APCDD1 variant. Here, APCDD1 is linked to malignant colon neoplasm.