Studies showed that patients at a late stage of BD presented decreased serum levels of brain-derived neurotrophic factor [15] and increased levels of inflammatory markers such as tumor necrosis factor-alpha (TNF-alpha) [15,16] and interleukin (IL)-6 [17], as well as the C-C motif ligand 11 (CCL11) [18]. Here, BDNF is linked to Behcet disease.