IGF1R and non-small cell lung carcinoma: Interestingly, in non-small cell lung cancer cells, resistance to EGFR inhibitors was attenuated upon incubation with EGFR tyrosine kinase and IGF1R pathway inhibitors, which synergistically induce apoptosis by blocking Akt phosphorylation and inducing the expression of FoXO-regulated pro-apoptotic genes [83].