IGF1 and lung cancer: Among other major components of the IGF axis, IGF1 is upregulated by the action of circRUNX1 on miR-145-5p or circ_0014130 on miR-142-5p, in colorectal [104] or nonsmall cell lung cancer [105], respectively, with substantial effects on cell proliferation, cell cycle progression, cell migration and inhibition of apoptosis.