A study conducted in murine glioma stem cells indicated that exposure to radiation increases IGF1 secretion, induces gradual increase in IGF1R expression, a decrease in phosphorylated Akt, activation of FoxO3a with consequent reduced proliferation, enhanced self-renewal through FoxO3 target genes and, ultimately, radioresistance [78]. This evidence concerns the gene FOXO3 and central nervous system cancer.