A retrospective study in 207 HCC patients who underwent hepatectomy demonstrated that the combined radiomics (gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid-enhanced MRI) and clinical model (AFP, gamma-glutamyltransferase, aspartate aminotransferase) showed the highest ability to predict the immunoscore, with an AUC of 0.934, a sensitivity of 0.846, a specificity of 0.841, an accuracy of 0.842, a positive predictive value of 0.611 and a negative predictive value of 0.949 [57]. This evidence concerns the gene AFP and hepatocellular carcinoma.