The study performed by Wang et al. used gadoxetic acid-enhanced MR images with a clinical model (AFP, irregular tumor margin, and arterial rim enhancement) in 227 patients with single HCC (training set 159 patients, a time-independent validated set 68 patients), and found a C-index of 0.846, with a sensitivity of 0.769 and a specificity of 0.818, for the identification of the cytokeratin 19 status of HCC [27]. This evidence concerns the gene AFP and hepatocellular carcinoma.