Plasma concentrations of ALT were significantly higher in NASH-fed animals compared to CTRL and chow-fed hamsters at one (p < 0.01), four (p < 0.01 and p < 0.05) and eight months (p < 0.0001), whereas plasma concentrations of AST were only transiently elevated compared to chow and CTRL at eight months (p < 0.05 and p < 0.001, Table 2). Here, GPT is linked to metabolic dysfunction-associated steatohepatitis.