Infiltration with CD68+ cells was seen in the NASH-fed hamsters (Figure 6G), and on image analysis CD68+ area fractions were significantly higher in these animals compared to those fed chow diet at four and 12 months (p < 0.01 and p < 0.05), and those fed CTRL diet at 12 months (p < 0.05, Figure 6A), however no significant differences between groups were seen at the eight-month time point. Here, CD68 is linked to metabolic dysfunction-associated steatohepatitis.