In GBM, increased Orai1 protein levels have been detected alongside higher SOCE activity in patient-derived primary tumor cells [244] and immortalized cell lines [245], while bioinformatic analyses conducted with deposited transcriptomic datasets found evidence of higher expression of ORAI2 in GBM samples compared to both lower-grade gliomas and normal brain samples [246]. The gene discussed is ORAI1; the disease is glioblastoma.