Intriguingly, in disagreement with the knowledge gathered from STX1 knockout (KO) mice in the context of the β-cell function, mice overexpressing STX1 in the islet β-cells showed decreased insulin exocytosis and perturbed activity of L-type Ca2+ channels, contributing to whole-body glucose intolerance [48]. The gene discussed is STX1A; the disease is Glucose intolerance.