There are few studies that describe the 5-HT2B receptor as a possible target for the treatment of anxiety, and some previous analyses indicate the anxiolytic activity of 5-HT2B agonists, such as BW723C86, which demonstrated this effect in the Vogel conflict and Geller–Seifter test [68] (tests based on associative learning), but was ineffective in the elevated plus-maze (EPM) test [69,70] (ethologically-based model). The gene discussed is HTR2B; the disease is Anxiety.