HTR1A and anxiety disorder: Tandospirone is a post-synaptic 5-HT1A receptor agonist and exerts its anxiolytic activity by inhibiting adenylate cyclase and activating GIRK, hyperpolarizing neurons from regions associated with anxiety disorders, such as the hippocampus and amygdala, where 5-HT1A receptors are expressed, consequently inhibiting local neuronal activity (Figure 3a–c) [24].