Interestingly, loss of MBNL1 function leads to changes in mTOR pathway [109] and the reduction of cyclin D3 in DM1 muscles due to abnormal increase of GSK3β switches the CUGBP1ACT to CUGBP1REP leading to a miss regulating myogenic CUGBP1 targets [110]. This evidence concerns the gene CELF1 and myotonic dystrophy type 1.