LPIN1 and Duchenne muscular dystrophy: Interestingly, similar results were reported by another previous study [97] using Duchenne muscular dystrophy (DMD) mouse model, where lipin-1 knockdown lead to changes of lipid metabolism in the skeletal muscles, resulting in increased phospholipid biosynthesis and a reduction of SERCA function leading to a pronounced muscle weakness (myopathy) [97].