Moreover, in additional cardiovascular diseases (e.g., atherosclerosis and hypertension) or in chronic disease associated with an increased risk of developing cardiovascular diseases (e.g., obesity or diabetes), priming is promoted by metabolites and/or neurohormonal activation (e.g., angiotensin II, fatty acids, and glucose) [38,39,40,41,42,43]. The gene discussed is AGT; the disease is hypertensive disorder.