NLRP3 inflammasome levels directly correlate with heart dysfunction, the levels of the N-terminal (NT) fragments of the pro-form of brain natriuretic peptide (BNP) (NT-proBNP, a marker of heart failure), and the rate of hospitalization in patients with dilated cardiomyopathy (DCM) [70]. Here, NPPB is linked to familial dilated cardiomyopathy.