APOE and atherosclerosis: For instance, P-selectin was targeted by gallium-68-labeled fucoidan PET for non-invasive characterization of vulnerable plaques in apolipoprotein E-deficient (ApoE−/−) mice [12], and an integrated 18F-fluorodeoxyglucose-PET (FDG-PET) and dynamic contrast enhancement MRI (DCE-MRI) imaging protocol was applied to noninvasively quantify lesion inflammation, neovasculature, permeability, and plaque burden in a rabbit model of atherosclerosis [13].