In this regard, defects in carnitine transporter (CTD, 5q mutation), carnitine-palmitoyl transferase 1 and 2 deficiencies (CPT-1 and CPT-2), the lack of carnitine acylcarnitine translocate (CACT, 3p21 mutation), have been linked to cardio-metabolic disorders that usually determine the onset of cardiomyopathy, arrhythmia, conduction disease and HF [107,122]. This evidence concerns the gene CPT2 and Arrhythmia.