Vinci et al. further confirmed the clonal nature of H3K27M, ATRX, and NF1 mutations, as well as the subclonal expansion of cells bearing mutations in TP53, BRAF, PDGFRA, among others, in pediatric GBM (pGBM) and DIPG [61]. The gene discussed is PDGFRA; the disease is glioblastoma.