PDGFRA and neoplasm: In addition to previously reported intra-tumor heterogeneity of EGFR amplifications [45,46], a subset of GBMs displayed mosaic amplifications in multiple RTKs, mainly involving EGFR, PDGFRA, and MET, with EGFR and PDGFRA co-amplification being the most common combinations, followed by EGFR and MET co-amplification.