AKT1 and neoplasm: The results also showed that this treatment increased the anticancer activity and apoptosis, decreased the epithelial to mesenchymal transition, reduced survival signals (EGFR, cyclin E, NF-κB, and PI3K/Akt pathway; Bcl-xL; and Bcl-2), decreased the density of microvessels, and eliminated CSCs in the tumor [149].