The treatment of ovarian cancer stem-like cells with DAPT (1–20 μM, 1–3 days) showed that the Notch blockade with DAPT significantly hampered ovarian CSC proliferation and the self-renewal ability, reduced the ovarian cancer stem cell (OCSC)-specific surface marker expression, and decreased the mRNA and protein expression of Sox2 and Oct4 in OCSCs [136]. The gene discussed is POU5F1; the disease is ovarian carcinoma.