It was demonstrated that treatment with 10 μmol/L of different GSIs (L-685,485 and DAPT) inhibited the growth of the epithelial cell adhesion molecule (EpCAM)-positive fraction in hepatocellular carcinoma cells, and in vivo Notch suppression caused significant antitumor effects in hepatomas, showing that Notch inhibition could block the stem cell properties of hepatic cancer cells [113]. The gene discussed is EPCAM; the disease is hepatocellular carcinoma.