PALB2 and Lynch syndrome: Genes currently widely advocated for definite inclusion or consideration of inclusion in germline PrCa sequencing panels in one or more of these contexts are ATM, BRCA1, BRCA2, DNA mismatch repair genes involved in Lynch syndrome (especially MSH2, however testing of MLH1, MSH6, PMS2 and potentially EPCAM is also generally advised) and HOXB13. The latest National Comprehensive Cancer Network (NCCN) guidelines for germline testing also propose screening CHEK2 and PALB2 as part of their minimum recommended predisposition gene panel [304].