HIF1A and hepatocellular carcinoma: As shown in Figure 7, the HIF-1α gene was similarly expressed in HCC and paired LC tissues (mean ± SEM expression level: 3.01 ± 0.35 vs. 3.47 ± 0.53) (Figure 7A), as was the protein in malignant and cirrhotic hepatocytes (mean ± SEM H-score: 97.91 ± 13.63 vs. 122.50 ± 14.02) (Figure 7B).