Most recently, THPO has been shown to play important and nonredundant paracrine/autocrine roles in other cellular systems, including human endothelial cells [10], liver sinusoidal endothelial cells in mice [11], hepatic progenitor cells in rats [12], and tumor cells from human lung, stomach, liver, and thyroid [13], suggesting a possible relationship between cancer and hemostatic disorders. Here, THPO is linked to cancer.