The hepatocyte expression of THPO protein was evaluated by IHC in HCC and corresponding LC samples; THPO protein levels were much higher in tumor cells than in associated cirrhotic liver, (mean ± SEM H-score: 124.50 ± 9.31 vs. 76.40 ± 8.05) (Figure 2A). The gene discussed is THPO; the disease is laryngotracheoesophageal cleft.