Comprehensive immunophenotyping alone (no TRBC1 analysis) did not show CD4-positive T-cells with tumor-specific immunophenotypic abnormalities in any of the patients without T-cell lymphoma, or in CTCL patients with no clonal CD4-positive T-cells detected by TRBC1 staining. Here, CD4 is linked to T-cell non-Hodgkin lymphoma.