AKT3 and neoplasm: Closer examination revealed that AKT3 ranked in the top part of both analyses (number 3 and number 2 in the tumour and cell line datasets, respectively), and importantly appeared to be strongly expressed in the majority of CMS4 cell lines and not at all or very lowly in CMS1-3 cell lines, whereas the other 5 kinases were also expressed in cultures assigned to a different CMS (Figure 1c,d).