TGFB1 and myeloproliferative disorder: As highlighted by several studies, MPN-associated monocytes, regardless of their mutational status, (i) secrete large amounts of cytokines, such as TNF-α, TGF-β and IL-10 [62], (ii) show impaired response to anti-inflammatory IL-10 (often elevated in MPNs) [63], (iii) stimulate osteoclastogenesis within the endosteal niche [64] and (iv) give origin to a population of clonal monocyte-derived fibrocytes, co-expressing markers of hematopoietic cells (e.g., CD34, CD45 and CD68) and stromal cells (e.g., collagen I, collagen III and fibronectin) involved in the induction of BM fibrosis in PMF [65].