Furthermore, a wide in vitro and in silico screening for potential MPN-specific neoantigens recently identified a total of 35 unique putative neoepitopes, deriving from abnormal CALR and MPL splicing variants, due to spliceosome defects, in MPN patients with SF3B1 mutations [135]. The gene discussed is SF3B1; the disease is myeloproliferative neoplasm.