Concerning breast cancer, based on current studies, iron, ACSL4 (Acyl-CoA synthetase long chain family member 4), PUFAs (polyunsaturated fatty acids), GPX4 (glutathione peroxidase-4) and p53 have been identified as vital regulators in ferroptosis pathway, also promising treatment targets for breast cancer. The gene discussed is ACSL4; the disease is breast carcinoma.