Zhang H et al. have reported that cisplatin and paclitaxel could promote secretion of miR-522 from CAFs (cancer-associated fibroblasts) via the USP7/hnRNPA1pathway, leading to ALOX15 suppression in gastric cancer cells, resulting in a poor therapeutic effect since the decreased chemosensitivity [25]. The gene discussed is USP7; the disease is gastric cancer.