EGFR and cancer: Some potential advantages of Fcy-hEGF protein include (1) overexpression of EGFR on cancer cells providing an enormous amount of binding site for Fcy-hEGF, thereby ensuring the generation of high local concentrations of 5-FU; (2) nuclear localizing property of EGFR may enhance DNA damages resulted from 5-FU generated by Fcy-hEGF; (3) low concentration of Fcy–hEGF at nM ranges of fusion protein is sufficient for inhibiting EGFR-overexpressing cancer cells in the presence of 5-FC [24].