Due to the EGFR-overexpressing human epithelial cancers responsible for approximately 50% of all cancer deaths, the aim of this study was to investigate the potential of a liposomal prodrug system, 188Re-liposome-Fcy-hEGF/5-FC, combining the cytotoxic effect of both radiotherapy and chemotherapy on EGFR-expressing cells. Here, EGFR is linked to cancer.