The effects of ALP on regulating phagocytic properties of reactive astrocytes may be one of the mechanisms that explains why tau protein enters astrocytes more efficiently than neurons, as observed in prior work [97] and has been implicated in the glial inclusions, as seen in most of the primary tauopathies, including PSP, CBD, and PiD [97]. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.