Recently, we established an ex vivo imaging system to detect the in vivo transamidation activity of TG2 based on the incorporation of a biotinylated substrate for TG2, 5-biotinamidopentylamine (5BAPA), in the liver of LPS and cecal ligation and puncture (CLP)-induced sepsis mouse model (Figure 3A,B) [22]. The gene discussed is TGM2; the disease is Sepsis.