MPNs include primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocythemia (ET) that can progress to AML, as well as the CML, which is characterized by the BCR-ABL1 translocation, the so-called Philadelphia chromosome. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.