Cresenzo and colleagues performed a whole transcriptome sequencing for anaplastic lymphoma kinase negative anaplastic large cell lymphoma (ALK-ALCL) samples where they recurrently found a NFkB2-TYK2 hybrid transcript in which the coding region of the NFkB2 is fused to TYK2 [55]. This evidence concerns the gene TYK2 and anaplastic large cell lymphoma.