TYK2 and acute lymphoblastic leukemia: In a broad study of Roberts et al., a detailed genomic analysis of 154 patients with BCR-ABL-like ALL was conducted, and ten JAK2 chimeras and a novel TYK2-MYB chimera were detected, with other kinase-activating rearrangements involving, e.g., cytokine receptor like factor 2 (CRLF2), EPOR, and thymic stromal lymphopoietin (TSLP) (these JAK-binding receptors are discussed also in the later chapters) [54].