To further elucidate the inhibitory mechanism, we investigated the effect of VP on the SRY (sex determining region Y)-box 10 (SOX10) and paired box gene 3 (PAX3) transcription factors that regulate melanoma markers such as protein melan-A (MART-1) and MITF expressed in melanoma cells [25,26,27]. This evidence concerns the gene PAX3 and melanoma.