Accordingly, a series of phase III clinical trials with VEGF inhibitors, such as bevacizumab (a humanized anti-VEGF-A monoclonal antibody), axitinib, or sorafenib with various drug combinations (gemcitabine or gemcitabine/erlotinib) in patients with advanced or metastatic PCa failed to improve OS (Table 1) [131,132,133,134]. Here, VEGFA is linked to posterior cortical atrophy.