BRCA1 and posterior cortical atrophy: A phase II clinical trial with olaparib, a small molecule PARP inhibitor, in a small cohort of BRCA1/2 mutated advanced PCa patients with gemcitabine resistance, evidenced a tumor response rate of 50.0% (4/8 patients), while 25% showed stable disease ≥8 weeks with a median overall survival (OS) of 9.8 months [20].