Although basal insulin analogues (glargine U100, detemir) provide a decrease in risk of nocturnal hypoglycaemia compared to human NPH insulin [39,40], and, in addition, second generation insulin analogues (degludec, glargine U300) proved to be better than insulin glargine U100 in this respect [41,42], the prevalence of nocturnal hypoglycaemia remained an important issue. Here, INS is linked to Hypoglycemia.