The authors analyzed ucfDNA fragments longer than 250 bp, corresponding to three oncogenes sequences: c-Myc, HER2, and BCAS1. These three oncogenes are frequently amplified in bladder cancers, mainly exhibiting their roles from pre-malignant tumor stage to primary invasive high-grade, as well as metastatic, bladder cancers [17,18,19]. Here, ERBB2 is linked to urinary bladder carcinoma.