Minerals including magnesium, potassium, and calcium, which play a role in regulating blood pressure by producing NO, regulating prostacyclin, and calcium channel blockade, by reducing the extracellular fluid volume modulating the activity of the renin-angiotensin system, and by inhibiting the parathyroid hormone, which induces hypertension [43]. The gene discussed is REN; the disease is hypertensive disorder.