ADAM17 and in situ carcinoma: Overall, significant differences in the expression levels of IHC markers between TC and IC were assessed for GATA3 (p < 0.001), IL-10R (p < 0.0001), and ADAM10 (p = 0.004) within MIBC, and for GATA3 (p < 0.0001), ADAM17 (p = 0.003), and ADAM10 (p = 0.007) within CIS (Figure 3A).