CRAT and alcoholic hepatitis: Transport of fatty acids across mitochondrial membrane relies on the carnitine system, components of which are dysregulated in the alcoholic hepatitis patients who received liver transplantation compared with the non-severe alcoholic hepatitis patients, including the upregulation of the carnitine palmitoyltransferase 1 (CPT1) isoform C and downregulation of CPT2 and the carnitine acetyltransferase (CRAT), which closes the carnitine cycle (Figure 5C,D).