Yuxuan Han et al. established luminal-type bone metastatic cell line by MCF7 cells [67] and profiled luminal type breast cancer metastatic signatures such as trefoil factor 1 (TFF1), interferon alpha inducible protein 6 (IFI6) and galectin 1 (LGALS1), which were confirmed as metastasis-positive signatures [143] (Table 3). Here, TFF1 is linked to breast carcinoma.