Among these, genes related to pluripotency or early neuronal development were particularly interesting, hence we have further analyzed and verified the regulation of a selected set of genes by Elk-1 using qPCR and investigated the regulation of SOX2, NANOG, and POU5F1 promoters by Elk-1 and its binding to predicted ets motifs in neuroblastoma and glioblastoma (GBM) cell lines. The gene discussed is SOX2; the disease is neuroblastoma.