KPC::Nrf2−/−-mice‒derived pancreatic cancer cell lines (KPCN lines 1 and 2) lack Nrf2, and KPC::K0N0 mice-derived cell lines (K0N0 line 1 and 2) lacked both Nrf2 and Keap1 expression. Here, KEAP1 is linked to familial pancreatic carcinoma.