Indeed, Pdx-1-Cre::K-rasLSL-G12D/+::p53LSL-R172H/+::Keap1fl/fl::Nrf2+/+ mice (KPC::Keap1 CKO mice) also exhibited pancreatic atrophy (but no pancreatic tumors; unpublished data). Here, PDX1 is linked to pancreatic neoplasm.