These cell lines were more susceptible to glutaminase inhibitors than cell lines lacking Keap1 and Nrf2. Furthermore, pretreatment of mutant K-ras expressing mouse and human pancreatic cancer cell lines with diethyl malate (DEM), an electrophilic stress inducer, sensitized the cells to a glutaminase inhibitor. The gene discussed is KEAP1; the disease is familial pancreatic carcinoma.