PDX1 and familial pancreatic carcinoma: Pdx-1-Cre::K-rasLSL-G12D/+::p53LSL-R172H/+::Keap1fl/fl::Nrf2+/− (KPC::K0N1) and Pdx-1-Cre::K-rasLSL-G12D/+::p53LSL-R172H/+::Keap1fl/fl::Nrf2−/−- (KPC::K0N0) mice developed invasive pancreatic cancers (2/31 and 2/17 mice, respectively) within 90 days of birth.