PRTN3 and periodontitis: Moreover, we recognized positive correlations between the severity of periodontitis, inflammatory parameters (especially CRP), serology (ACPA status and titers), and RA activity; indeed, recent studies suggest a worse periodontal status in active untreated RA, and higher CRP if RA is associated with severe periodontitis [6,11,15,16,17,19,27,28,37].