Considered as the cytokine signature, the aberrant activation of TNF-α and IL-6 regulates immune response and bone metabolism in RA [1,3,5,6,16]; high concentrations of both cytokines were detected in serum, synovial tissues, as well as synovial fluids [18,27], positively correlating with disease activity [28]. This evidence concerns the gene TNF and rheumatoid arthritis.