On the other hand, RA patients experience a greater risk of PD, irrespective of disease duration, especially in ACPA-positive subtype [1,2,3,6,7,8,11,14,19]; moreover, they are prone to develop moderate to severe periodontitis in established compared to early disease [6,7,8,9,14,19,23]. Here, PRTN3 is linked to periodontitis.