Indeed, numerous studies indicated a rapid and significant decline in typical inflammatory parameters (ESR and CRP), but also in serological RA biomarkers (RF, ACPA) as well as inflammatory cytokines (TNF, IL-6) and mediators (serum-amyloid A, matrixmetaloproteinases 1, 3), supporting the indirect role of TCZ in periodontitis [16,17,27,28]. This evidence concerns the gene IL6 and periodontitis.