ITGA2B and autoimmune thrombocytopenic purpura: Platelets can bind immunoglobulins (attached to viruses) via Fc-gamma-RII receptors leading to platelet activation, aggregation and clearance [46,47], while immunoglobulins produced by B-lymphocytes that target viruses can cross-react with platelet surface integrins (GPIIb/IIIa or GPIb-IX-V) leading to immune thrombocytopenia (ITP) [48].