Thrombocytopenia is a predictor of such adverse outcomes, especially when combined in clinical scoring systems with other parameters such as age, gamma-glutamyl transpeptidase, Alanine and Aspartate aminotransferase [7,8,9,10,13,14,15,17,19,120,121,122] However, in individuals that have already developed HCC, thrombocytosis carries a negative prognosis rather than thrombocytopenia. This evidence concerns the gene GGTLC1 and hepatocellular carcinoma.