CD44 and neoplasm: In MDA-MB-231, CD44-T-PNPs/Rhod had 2.5 folds better tumor accumulation compared to NT-PNPs/Rhod, as shown in Figure 4A. While in MDA-MB-468, the CD44-T-PNPs had 2.1 folds better tumor accumulation compared to NT-PNPs, as shown in Figure 4B. Higher cellular uptake of CD44-T-PNPs affirmed in both cell lines is probably due to receptor-mediated endocytosis followed by HA/CD44 interaction.